What Genes Are Most Commonly Linked to Cancer Risk?

 

Cancer is a condition that develops when cells grow uncontrollably, and while lifestyle and environmental factors play a role, our genes can also influence cancer risk. Some people inherit genetic mutations that increase their chances of developing specific types of cancer. Learning about these genes is important because it allows early detection, prevention, and timely treatment.

The most widely known cancer-related genes are BRCA1 and BRCA2. Mutations in these genes are strongly linked to breast and ovarian cancer, and in some cases, prostate and pancreatic cancers as well. Women and men who carry these mutations are often advised to undergo regular screening to detect cancer at an early stage.

Another important gene is TP53, which helps control cell growth and division. Mutations in TP53 are connected to a wide range of cancers, including lung, breast, and brain cancers. Similarly, MLH1, MSH2, MSH6, and PMS2 are genes linked to Lynch syndrome, which increases the risk of colorectal, stomach, and endometrial cancers.

The APC gene is another significant gene associated with colon cancer, especially in people with a condition called familial adenomatous polyposis (FAP). In addition, mutations in RET and VHL genes are linked to thyroid and kidney cancers, respectively.

It is important to understand that having a genetic mutation does not mean a person will definitely get cancer, but the risk is much higher compared to someone without these mutations. This is why genetic testing and counseling are highly recommended for individuals with a strong family history of cancer. Early detection and preventive strategies, such as regular screenings, lifestyle modifications, and in some cases preventive treatments, can greatly reduce the risk.

If you or your family members are concerned about inherited cancer risks, consulting the Best Genetic Cancer Doctor in Delhi can provide the right guidance. A specialist can help identify if you need genetic testing, explain your results in detail, and create a personalized monitoring and prevention plan. Taking proactive steps today with expert advice can make a huge difference in safeguarding your health and future.