What Role Does Genetics Play in Colorectal Cancer Risk?

 

Colorectal cancer, which affects the colon and rectum, is among the most commonly diagnosed cancers worldwide. While lifestyle factors such as poor diet, smoking, alcohol consumption, and lack of physical activity are well-known contributors, genetics also plays a significant role in increasing an individual’s risk of developing this disease.

If you have a family history of colorectal cancer, your risk of developing it is considerably higher. Studies show that having one or more first-degree relatives (parents, siblings, or children) diagnosed with colorectal cancer can double your chances of developing the disease. This increased risk is often due to inherited genetic mutations that lead to abnormal cell growth in the colon or rectum.

Some of the most well-known inherited genetic conditions linked to colorectal cancer include Lynch syndrome and Familial Adenomatous Polyposis (FAP).

• Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is caused by mutations in DNA mismatch repair genes. People with Lynch syndrome have a significantly higher risk of developing colorectal cancer at a younger age, as well as other types of cancer, including endometrial and ovarian cancer.

• Familial Adenomatous Polyposis (FAP) is a rare inherited disorder where hundreds to thousands of polyps form in the colon and rectum, significantly increasing the risk of cancer if left untreated.

Even if there is no clear family history of colorectal cancer, some individuals may carry genetic mutations that predispose them to the disease. Genetic testing can help identify these mutations early, allowing for preventive measures, more frequent screening, or early intervention before cancer develops.

For those at high genetic risk, regular screening tests such as colonoscopy are strongly recommended to detect precancerous polyps or early-stage cancer, where treatment is most effective. In some cases, preventive surgery may even be advised.

Consulting a Colorectal Cancer Specialist in Delhi NCR is essential for anyone concerned about genetic risks. These specialists are highly trained in genetic risk assessment, early detection, and creating personalized care plans based on your genetic profile and medical history. They can recommend appropriate genetic tests, explain the implications of the results, and suggest the best preventive strategies or treatment options.

Early diagnosis and expert guidance significantly improve the chances of successful treatment and long-term health. If colorectal cancer runs in your family or if you are concerned about your genetic risk, do not delay consulting a specialist. A trusted Colorectal Cancer Specialist in Delhi NCR will help you understand your risk and provide the most advanced care to protect your health.